Dr.Wafaa El Wady
Professor and chief department of Oral Surgery in the Consultation Center of Dental Treatments of Rabat
Title: VIROINDUCED ORAL CANCERS
Biography
Biography: Dr.Wafaa El Wady
Abstract
Oral cavity cancers are in sixth place in men and the eighth in women worldwide. They are often favored by alcohol intoxication and/or smoking but approximately 25% of these cancers are virus-induced tumors. Four viruses are clearly associated with the occurrence of some forms of cancer of the oral cavity.rnThe human papilloma virus (HPV) belongs to the family of the Papillomaviridae. It’s an extremely common virus in the nature with sexual transmission. Some high-risk genotypes are considered as agents who may increase thecancer risk of the upper aerodigestive tract. These cancers are a distinct clinical entity and develop in young patients not necessarily subject to Ethylo tobacco intoxication.They mostly affect the oropharynx, invade the lymph nodes and are poorly differentiated histologically.rnEpstein-Barr virus (EBV) a member of the Herpesviridae family that infects most of the world's population. In the oral cavity, EBV,transmitted by saliva is associated with Burkitt's lymphoma. It is an aggressive form of non-Hodgkin lymphoma due to the malignant proliferation of cells B. There are three types of Burkitt: endemic, sporadic and linked to HIV infection, which are associated with significant differences in epidemiology, clinical form and biology.rnThe human herpesvirus 8 (HHV-8), also called KaposiSarcoma Herpesvirus (KSHV) is considered as the etiologic agent of Kaposi's sarcoma. It’s a malignant multifocal mesenchymal tumor of blood and lymph vessels. There are four types of sarcoma: classic, endemic, iatrogenic and epidemic HIV associated, which are involved with significant differences in clinical and epidemiological aspects.rnThe Hepatitis C virus (HCV) is an RNA virus belonging to the Flaviviridae family. It is transmitted primarily through blood. At the oral cavity, HCV is associated with oral lichen planus (OLP). It is a chronic inflammatory skin disease, characterized by a keratinization disorder with polymorphic clinical aspects. During its evolution, the OLP has an increased risk of malignant transformation leading to the development of a verrucous or squamous cell carcinoma.rn